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Literature summary extracted from

  • Hess, R.; Wujak, L.; Hesse, C.; Sewald, K.; Jonigk, D.; Warnecke, G.; Fieguth, H.G.; de Maat, S.; Maas, C.; Bonella, F.; Preissner, K.T.; Weiss, B.; Schaefer, L.; Kuebler, W.M.; Markart, P.; Wygrecka, M.
    Coagulation factor XII regulates inflammatory responses in human lungs (2017), Thromb. Haemost., 117, 1896-1907 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.38 C1INH
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 factor XI + H2O Homo sapiens
-
 factor XIa + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 factor XIIa
-
 Homo sapiens
3.4.21.38 FXIIa
-
 Homo sapiens
3.4.21.38 Hageman factor
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.38 physiological function the enzyme induces activation of Erk1/2 and Akt in precision cut lung slices. Enzyme accumulation in acute respiratory distress syndrome lungs contributes to the release of pro-inflammatory mediators like interleukin (IL)-8, IL-1beta, IL-6, leukemia inhibitory factor, CXCL5 and tissue necrosis factor-alpha Homo sapiens